MOLECULAR TOPOLOGY
Humanetics employs a highly sophisticated, proprietary methodology to target and discover new biotherapeutic compounds based upon the science of molecular topology. Molecular topology is a science that allows molecules to be numerically described according to the arrangement of atoms within the molecule. The resulting numeric molecular signature can be analyzed and manipulated mathematically to find correlations with biological, physical and chemical properties of the molecule. Molecular topology offers a vastly more efficient process than traditional structure bound methods and removes the considerable time, cost and uncertainty of conducting wet chemistry experiments on hundreds of thousands of molecules in high throughput biochemical screens that generate a lot of false data. Specifically, use of molecular topology as the engine for our pipeline screening and discovery process provides the following specific advantages:
Speed. We can compress the discovery process from years down to weeks,
Cost. We estimate the discovery costs to be at least one order of magnitude less expensive,
Efficiency. The process provides a 3 to 4 log reduction in number of compounds needed for testing (e.g 20 instead of 100,000 to 1 million), and
Utility. Most importantly, we end with novel compounds with greater probability of success, since multiple property parameters are incorporated.
Humanetics has exclusive rights, within its technology platforms, to the Forward Engineering[tm] molecular topology tool from Medisyn Technologies. The Forward Engineering[tm] tool has reduced the science to practice in functional software. This software platform allows algorithms to learn from a training set of compounds (that share a common property and/or activity) what mathematical similarity the compounds all share and that, in turn, relates to their common activity. This software tool allows Humanetics a distinct competitive advantage by providing a rapid methodology to not only analyze properties of compounds, but remarkably, to also discover novel, patentable and diverse structures for a specified property or combination of properties.
